CRB3 and neoplasm: CRB3, an important apical protein, is significantly reduced in various tumor cells and tissues, as well as promotes metastasis and tumor formation in nude mice (Li et al., 2017; Mao et al., 2017; Karp et al., 2008; Li et al., 2018; Thiery et al., 2009; Varelas et al., 2010).