Our previous studies have shown that CRB3 is expressed at low levels in renal and breast cancers, and abnormal CRB3 expression leads to the disrupted organization of MCF10A cells in three-dimensional (3D) cultures (Li et al., 2017; Mao et al., 2017; Mao et al., 2015). The gene discussed is CRB3; the disease is breast carcinoma.