SQSTM1 and COVID-19: Although the focus of this study was the acute response of the heart to SARS-CoV-2 infection, alterations in p62, GSK3α/β, and ERK1/2, along with the innate immune response and cardiac inflammation, may shed some insight into postacute sequelae of COVID-19 or “long COVID.” Long COVID is poorly defined because of the number and variations in reported symptoms, but it is generally characterized as a prolongation or reoccurrence of COVID-19 symptoms 3 mo from diagnosis and lasting for at least 2 mo, without an alternate diagnosis (51).