It is of interest that in the study GSE178671, where recurrent and non-recurrent endometrial cancer were compared, the DEGs were involved in the IGFR1 cascade signalling, signalling by type 1 insulin-like growth factor-1 receptor, IRS-related events triggered by IGF1R, all of which are within the MAPK signalling pathway (Supplementary File 11 and Table 3 within Supplementary File 11). Here, IARS1 is linked to endometrial cancer.