Furthermore, when we investigated the pathways associated with the 54 DEGs in skeletal muscle of PCOS patients from two different studies (GSE8157 [20] and GSE6798 [21]), gene enrichment of the up regulated genes revealed that the genes were involved in: (1) activation of RAC1 downstream of NMDARs, (2) behaviour and (3) multicellular organismal homeostasis. The gene discussed is RAC1; the disease is polycystic ovary syndrome.