Both IGF1 and INSR were however down regulated in PCOS and EC patients, when we looked at the DEGs that were common between all PCOS datasets and all EC datasets, except for one dataset (GSE178671) where it was up regulated in recurrent endometrial cancer stage IB in comparison to non-recurrent endometrial cancer stage IB. The gene discussed is IGF1; the disease is polycystic ovary syndrome.