IL6 and neoplasm: First, it explains the “Oppenheimer phenomenon”, where long‐term PLA implantation results in neoplasia in some humans and up to 80% of rodents[6] since IL‐6 directly links persistent inflammation from PLA to cellular transformation.[47] Second, stimulating IL‐10 is critical to tissue repair by driving wound resolution and angiogenesis.[48] In fact, IL‐10 is a key immunomodulatory cytokine secreted by mesenchymal stem cells,[49] and is crucial in macrophage‐stem cell crosstalk[50] for tissue engineering.