Unprimed, mock-infected primary hMDMs had basal caspase-5 expression, and IFN-γ priming led to processed caspase-5 p35 subunit in primary hMDMs and THP-1 cells, suggesting that caspase-5 may be constitutively expressed and undergoes some autoprocessing regardless of infection status (Fig. 1F). The gene discussed is IFNG; the disease is infection.