For example, the knockdown of KLF9 in cardiomyocytes protects them from ischemic injury (Yan et al., 2019), and a KLF9-dependent increase in ROS can result in cell death in lung tissues (Zucker et al., 2014) and induce proliferation of melanoma (Bagati et al., 2019). The gene discussed is KLF9; the disease is melanoma.