Moreover, a less stringent set of MPHL-associated genes overlapped with and were enriched for genes that have been reported as the cause of monogenic trichoses, namely WNT10A (odonto-onycho-dermal dysplasia and Schöpf-Schulz-Passarge syndrome), HOXC13 (pure hair and nail ectodermal dysplasia), DSP (Carvajal syndrome), LPAR6 (hypotrichosis 6), ALX4 (total alopecia in frontonasal dysplasia), EDAR (ectodermal dysplasia), CDH3 (ectodermal dysplasia), HR (hypotrichosis 4 and alopecia universalis), and SPINK5 (Netherton syndrome). The gene discussed is SPINK5; the disease is pure hair and nail ectodermal dysplasia.