And in vivo experiment of a xenograft mouse model by injecting TGF-β knockout A2780 cells into mouse subcutaneously demonstrated that in comparison to the control group, the TGF-β knockout group exhibited sharp inhibition in ovarian tumor growth, which showed that only one mouse developed a very small tumor in TGF-β knockout group (Fig. 7o, p), implying that depletion of PRMT1 attenuated ovarian tumor growth. The gene discussed is PRMT1; the disease is ovarian neoplasm.