This negative relationship between HPRT1 expression and GBM patient survival was also reproduced in different datasets, including the Gravendeel (P = 0.014)32, Freije (P = 0.0152)33, Nutt (P = 0.0248)34 (Fig. 8b), Joo (P = 0.4208)35, and Phillips (P = 0.2622)36 (Supplementary Fig. 12d). Here, HPRT1 is linked to glioblastoma.