Notably, the expression pattern of PD-1 and TOX in TCF1+ and TCF1- CD8+ T cells during acute GvHD was the opposite between 7 and 28 dpt (Figs. 1E, H, and Supplementary Fig. 5), and this phenomenon was also observed in chronically infected mice (Figs. 1E, H, and Supplementary Fig. 6). The gene discussed is TOX; the disease is graft versus host disease.