They also identified that PHLPP2 mediated the stabilization of BECN1/Beclin1 indirectly by cullin 4A (CUL4A) and promoted autophagy.40 In other words, the connection between PHLPP2 and autophagy is not direct, and accordingly, the association of PHLPP2 with autophagy in cancers needs to be explored. This evidence concerns the gene BECN1 and cancer.