AKT1 and cancer: It inactivates Akt via the dephosphorylation of serine 473.30,31 Similarly, PHLPP inactivates PKC via the dephosphorylation of serine 657 (in PCKα).32 Accordingly, PHLPP expression suppresses cell survival and promotes cell apoptosis in cancer cells.29,30 Accordingly, the PHLPP2 gene is described as a tumor suppressor, as it promotes cell apoptosis and suppresses cell proliferation, invasion, and tumor growth by acting as an antagonist of the PI3K/AKT signaling.33-37