Accordingly, we speculated that the association of PHLPP2 with the development and prognosis of READ may be associated with various signaling pathways, including “hsa04151: PI3K-Akt signaling pathway,” “hsa04068: FoxO signaling pathway,” “hsa04370: VEGF signaling pathway,” “hsa04066: HIF-1 signaling pathway,” “hsa04630: JAK-STAT signaling pathway,” “hsa04668: TNF signaling pathway,” “hsa04010: MAPK signaling pathway,” and “hsa04210: Apoptosis.” This evidence concerns the gene AKT1 and reading.