In addition, the augmented IRG1 and itaconate in peritoneal tissue-resident macrophage has also been associated with the promotion of peritoneal tumor cell growth by the boosted oxidative phosphorylation-driven ROS production in macrophages and ROS-mediated activation of MAPK in tumor cells, which leads to the enhanced peritoneal tumor progression [34]. Here, ACOD1 is linked to neoplasm.