ACOD1 and hepatocellular carcinoma: Thereout, in order to investigate the underlying roles of IRG1 in hepatocarcinogenesis, we used the chemical carcinogen diethylnitrosamine (DEN)-induced HCC mouse model, and found that DEN administration significantly enhanced IRG1 expression in hepatocytes, and knockout of hepatic IRG1 markedly suppressed DEN-induced HCC, suggesting the potential tumor-promotive roles of IRG1 in hepatocarcinogenesis.