ACOD1 and hepatocellular carcinoma: Furthermore, using STAM hepatocarcinogenesis model with streptozotocin and high-fat diet, which was the most molecularly similar to human HCC among the available hepatocarcinogenesis mouse models [26], the induced HCC was also markedly inhibited in Irg1hep-/- mice (Fig. 1F, G), and hepatic Irg1 expression was increased during STAM induction process (Supplementary Fig. 1F).