Recently, a number of immune markers (e.g., HER2, EGFR, CD44v9, PD-L1, Nectin-4, MUC1, claspin) have been reported as predictive markers for poor prognosis or high-grade UC in patients with UTUC [4–8]. This evidence concerns the gene EGFR and renal pelvis/ureter urothelial carcinoma.