Moreover, according to Fujii et al., UTUC can be divided into five DNA-based molecular subtypes such as hypermutated, TP53/MDM2, RAS, FGFR3, and triple negative, and 50.6% of ureter UC was TP53/MDM2 mutational subtype [30]. Here, MDM2 is linked to renal pelvis/ureter urothelial carcinoma.