However, we found that the expression of IFN-β was upregulated in the CNS of Irf7−/− Ifnβ+/Δluc mice 7 days post-infection compared to WT Ifnβ+/Δluc and Irf3−/− Ifnβ+/Δluc animals. The gene discussed is IFNB1; the disease is infection.