Whereas IRF3-deficient mice mostly survived neurotropic infections with normal IFN-I induction in the periphery, IRF7 is needed for proper peripheral IFN-I responses and survival of several virus infections, e.g., with Encephalomyocarditis virus (EMCV), Herpes simplex virus (HSV-1), WNV or Oropouche virus (ORO) [11, 34, 35]. The gene discussed is IRF3; the disease is viral infectious disease.