Interestingly, human MSC-exosomal miR-627-5p has been demonstrated to ameliorate non-alcoholic fatty liver disease via downregulating FTO expression [57], which indicates the inhibitory effect of FTO expression by MSC-exosomes may be mediated via exosomal miR-627-5p as well in this study. Here, FTO is linked to metabolic dysfunction-associated steatotic liver disease.