Therefore, this study aimed to develop, test, and validate a clinic-radiologic (CR) model based on CE-CT imaging features, a rad-score model based on three phases of CE-CT imaging radiomics features, and a combined clinic-radiologic-radiomic (CRR) model to predict Ki-67 expression in HCC preoperatively, then compare the stability of the CR and rad-score model, and investigate the added value of radiomics features. This evidence concerns the gene MKI67 and hepatocellular carcinoma.