Cluster analysis based on m6A features revealed that subgroups of m6AregC1 (characterized with high expression of IGF2BP3) and m6AsigC1 (characterized with immune activation, with high CD8+ effector T cells, transcripts of immune activation, and immune checkpoints) were characterized by activation of inflammatory pathways and infiltration of inflammatory cells, and these subgroups were more responsive for CRC immunotherapy (Zhang et al. 2022b). Here, CD8A is linked to colorectal carcinoma.