Our results demonstrated that TUG1 rs5749201 and rs886471 gene polymorphisms were associated with an increase in the risk of SLE and significantly increased the susceptibility of LN where the AA, AT, and A alleles of rs5749201 and the GG, GT, and G alleles of rs886471, in addition to the dominant of both SNPs, had a higher risk of SLE. Here, TUG1 is linked to systemic lupus erythematosus.