Then, coordinated tumor cell migration is carried out with additional cellular processes, including the activation of the “angiogenic switch”, characterized by a change in the local balance of proangiogenic factors, such as the vascular endothelial growth factor (VEGF), and antiangiogenic factors, including thrombospondins and endostatins, among others, which indicates that angiogenesis is a key mechanism for tumor growth and invasive behavior [22]. The gene discussed is COL18A1; the disease is neoplasm.