For instance, Xu et al. demonstrated that the circular RNA known as circIKBKB activates the NF-κB pathway by promoting the IKKβ-mediated phosphorylation of IκBα, resulting in the inhibition of the IκBα feedback loop and facilitating the binding of NF-κB to the promoters of multiple bone-remodeling genes, stimulating breast cancer metastasis to bone [39]. This evidence concerns the gene NFKBIA and breast carcinoma.