VEGF-C, a growth factor of the vascular endothelial growth factor family receptors, endothelin 1, and SDF-1 exhibit a high pro-angiogenic activity by promoting mitosis and inhibiting apoptosis on endothelial cells, resulting in an increased vascular permeability and a promotion of cell migration, favoring tumor angiogenesis. The gene discussed is EDN1; the disease is neoplasm.