Consistent with reports of hippocampal LTP attenuation, altered dendritic pathology, and spinal loss in hippocampal neurons in human brain tissue from patients with epilepsy or animal models of epilepsy,27, 29 we found that inhibition of S6K1 counteracted the abnormal dendritic morphology due to recurrent seizures. The gene discussed is RPS6KB1; the disease is epilepsy.