IGHE and appendicitis: On the other hand, recent works showed an increase of IgE cells [7–9], as well as a predominance of eosinophilic infiltration [10–12] in phlegmonous (uncomplicated) appendicitis but not in complicated appendicitis, which reinforces the idea that uncomplicated appendicitis may be immune-mediated by an allergic-type I hypersensitivity reaction.