HMGA2 and neoplasm: Moreover, angiogenesis in OSCC is associated with the parameters of size (T) and lymph node involvement (N), a reliable indicator of tumor relapse.11 HMGA2 regulates OSCC angiogenesis-related genes and correlates with both distant and lymph node metastasis.421 Patients with high HMGA2 expression have a worse 5-year survival rate.