Therefore, PNI in OSCC can be predicted by a high expression of NGF and tyrosine kinase A. The overexpression of PNI and NGF can also lead to pain in OSCC patients.427 Taken together, the expression of PNI and NGF is capable of determining the aggressiveness and prognosis of oral cancers in patients.427. The gene discussed is NGF; the disease is lip and oral cavity carcinoma.