CDKN2A and neoplasm: Of note, HPV+ and p16+ patients have a higher overall survival rate than HPV- or HPV+ but p16- patients.438 When p53 interacts with E6 encoded by carcinogenic types of HPV (such as HPV-16 and HPV-18), it is proteolyzed by ubiquitin-dependent proteases.434 There is a significant difference between the level of wild-type p53 in HPV+ neoplasms and the elevated possibility of p53 mutations in HPV- tumors, which is related to a favorable prognosis for HPV+ OSSC patients.53