80%-90% of head and neck squamous cell carcinoma (HNSCC) is found to overexpress epidermal growth factor receptors (EGFR), a member of the HER/ErbB family of receptor tyrosine kinases (RTKs).88–90 It has been reported that OSCC shows increased EGFR (42% to 58%),91 which is associated with poor treatment outcomes and prognosis.92 This evidence concerns the gene NTRK1 and head and neck squamous cell carcinoma.