Thirty-seven percent of HNSCC cases, more specifically 34% of HPV- and 56% of HPV+ patients, exhibit overexpression or mutation of PIK3CA, as reported by the Cancer Genome Atlas (TCGA) study.99,100 Furthermore, patients with OSCC are more likely to exhibit somatic copy number alterations in genes encoding components of the PI3K/AKT/mTOR network.71,101–103. This evidence concerns the gene PIK3CA and head and neck squamous cell carcinoma.