FAM3C and intraepithelial neoplasia: Compared to healthy mucosa and epithelial dysplasia, the level of FAM3C in OSCC specimens increases, and patients with a higher FAM3C expression are more likely to have a poor prognosis.442 In addition, the expression of FAM3C correlates positively with immune checkpoints such as PD-L1, VISTA, and B7-H4, the EMT marker Slug, and the CSC markers SOX2 and ALDH1.442