Of these IRGs, 6 were positively correlated with DLD in AD (GPI, IREB2, PDK1, PSMC1, PSMC2, and TUBB3), and 4 were negatively correlated with DLD in AD (CAT, CD4, PPARD, and RXRA) (Supplementary Figure S1). Here, PSMC2 is linked to Alzheimer disease.