Of these IRGs, 23 were positively correlated with PLAAT4 in AD (AKT1, B2M, BST2, HLA-B, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DRA, HLA-E, HLA-F, IFITM1, IRF7, IRF9, LTBP1, MAVS, OASL, PRDX1, PSMB8, S100A2, TAP1, TLR2, TLR3, and TNFAIP3), and 2 were negatively correlated with PLAAT4 in AD (CD8A and HSP90AB1) (Supplementary Figure S2). Here, HSP90AB1 is linked to Alzheimer disease.