Similar phenomena have been observed in other tumors; glioma stem cells with high aldehyde dehydrogenase isoform 1 (ALDH1) expression, which are highly resistant to standard treatment regimens, are sensitive to ferroptosis induced by the ferroptosis inducer RSL3, and their sensitivity increases with the expression level of ALDH1 (35). The gene discussed is ALDH1A1; the disease is glioma.