Salvianolic acid A treatment could suppress the malignant behaviors of glioma cells and improve TMZ sensitivity through inactivating TAGLN2/PI3K/Akt pathway (32); Bodo Haas at al. also indicated that PI3K pathway seems to play a crucial role in resistance to alkylating agents and might serve as drug target for chemosensitization (33). The gene discussed is AKT1; the disease is central nervous system cancer.