FASN and metabolic dysfunction-associated steatohepatitis: In HFD-induced NASH, trans-chalcone was effective in reducing hepatic lipogenesis by down-regulating the levels of the hepatic fatty acid synthase (FAS) enzyme, sterol regulatory element-binding protein (SREBP)-1c, SREBP-2, and peroxisome proliferator-activated receptor (PPAR)-γ2 (10).