NFE2L2 and cataract: The neuroprotective effects of safranal on retinal degeneration were shown to be mediated by inhibiting photoreceptor cells (101, 102), A recent study investigated the protective effect of safranal on cataracts in rats and found that subcutaneous injection of sodium selenite in rats produced considerable cataracts and increased the level of lipid peroxidation (MDA) but decreased the level of GSH and Nrf2 protein.