PRRX1 and neoplasm: As shown in Fig. 6F and Fig. S17, ZNF469 expression was positively correlated with PRRX1 expression levels in breast invasive carcinoma (BRCA) (r^Pearson = 0.62, P < 0.001), which suggests that ZNF469 may be associated with tumor metastasis, affecting breast cancer progression, and may provide useful information for early clinical diagnosis, new therapies, and targeted treatments.