The addition of CD4+CD25+CD127low UCB-Tregs to the proliferating SLE-PBMCs significantly decreased the secreted IL-1α levels to 12 ± 0 pg/ml at 3 days (p = 0.0029) and 61 ± 6 pg/ml at 7 days (p = 0.0106; Figure 2H). The gene discussed is CD4; the disease is systemic lupus erythematosus.