CD4 and systemic lupus erythematosus: (iii) TNF-α: Significantly higher TNF-α levels of 9,342 ± 202 pg/ml at 3 days and 13,426 ± 333 pg/ml at 7 days were secreted by SLE-PBMCs when compared to CD4+CD25+CD127low UCB-Tregs alone levels of 358 ± 45 pg/ml and 355 ± 24 pg/ml, at the corresponding time points (p < 0.0001).