As shown in Figures 2B–I, CD4+CD25+CD127low UCB-Tregs were able to suppress several inflammatory cytokines secreted by SLE-PBMCs in their co-culture supernatants on days 3 and 7, including the following: (i) IFN-γ: Significantly higher IFN-γ levels of 29,264 ± 1,867 pg/ml and 72,080 ± 2,379 pg/ml were secreted by SLE-PBMCs alone at days 3 and 7, respectively, when compared to CD4+CD25+CD127low UCB-Tregs alone levels of 32 ± 3 pg/ml and 149 ± 16 pg/ml at the same time points (p < 0.0001). This evidence concerns the gene CD4 and systemic lupus erythematosus.