The addition of CD4+CD25+CD127low UCB-Tregs to the proliferating SLE-PBMCs significantly decreased the secreted sCD40L level to 124 ± 3 pg/ml at 3 days (p = 0.0006) and 177 ± 13 pg/ml at 7 days (p = 0.0336; Figure 2G). This evidence concerns the gene CD4 and systemic lupus erythematosus.