TNFRSF1B and colitis: In the Il10−/− Th1/Th17-like spontaneous colitis model, in which disease can be exacerbated by co-deletion of TNFR1,18 we found upregulation of Tnfr2 to be associated with colitis in both Il10−/− and Il10−/− Tnfr1−/− mice (Figures 1F, 1G, and 1J).