PDK4 and cancer: The higher expression of TM4SF20 (transmembrane 4L six family member 20, a gene involved in cell proliferation, motility, and cell adhesion), of CPTA1 (carnitine palmitoyltransferase 1A, which can promote cancer cell proliferation), and of PDK4 (pyruvate dehydrogenase kinase 4, a gene that influences cell proliferation) supports the effects of perfusion in stimulating growth, reproduction, and differentiation of the Caco-2 cells.