qRT‐PCR and immunohistochemistry manifested that overexpression of NRF1 elevated NRF1, METTL3, and GLRX expression in PD mice, while further knockdown of METTL3 diminished METTL3 and GLRX expression in the presence of overexpression of NRF1 (Figure 5A,B). The gene discussed is METTL3; the disease is Parkinson disease.