These findings corroborate our results, in which during DCM development, circMAP3K5 exerted the ceRNA mechanism as a sponge chelating agent of miR‐22‐3p to inhibit its expression, and downregulate and upregulate miR‐22‐3p and downstream DAPK2 expression, respectively. This evidence concerns the gene DAPK2 and familial dilated cardiomyopathy.