A similar concept can be used in melanoma, as reported, exosomal miR‐181a/b, miR‐122, miR‐498, miR149 and miR‐3187‐3p are immunomodulators of T‐cell receptor (TCR) signalling that downregulate T‐cell response and induce TNF‐α secretion to suppress CD8 T‐cell activation.129. This evidence concerns the gene CD8A and melanoma.