The study elaborated that increased lncRNA‐NKILA expression increased K48‐polyubiquitination‐mediated degradation, which mediated degradation of antigen peptide‐loading complex and the intrinsic tumour suppressor genes (Rb and p53), leading to resistance to anti‐PD‐1 drugs and tumour metastasis. This evidence concerns the gene RB1 and neoplasm.