EGFR and non-small cell lung carcinoma: Interestingly an in vitro study performed comprehensive circRNA profiling of NSCLC cell lines (H1975/AZDR and HCC827/AZDR) and demonstrated that circC3 (circ_0002130) was significantly upregulated in cells that exhibited resistance to Osimertinib (AZD9291), an EGFR tyrosine kinase inhibitor.69