For UCEC and ESCC, CYFIP2 was found to have an unfavorable effect on OS (HR = 2.74, 95% CI 1.76–4.26, log-rank P < 0.01; HR = 3.21, 95% CI 1.17–8.79, log-rank P = 0.018). The gene discussed is CYFIP2; the disease is esophageal squamous cell carcinoma.