The mean age of hospital presentation (63.89 ± 12.94 years), serum creatinine (127.75 ± 108.03 μmol/L) and urea (7.857 ± 3.643 mmol/L) were the highest (all P < 0.001) and ANA-positive (ANA ≥ 1:100, 93.7%), anti-SSB-positive (29.8%) and anti-scl-70-positive (3.5%) were more prevalent in the G1 group (pSS patients with eGFR < 60 mL/min/1.73 m2) among all groups. This evidence concerns the gene SSB and peeling skin syndrome.