NUR77 was found to be highly expressed on brain tissue in a cerebral ischemia model [37], aortic endothelial cells in an atherosclerosis model [9], and hepatocytes in an animal model of nonalcoholic fatty liver [38], and directly associated with mitochondrial dysfunction, impaired ATP energy production, and apoptosis. The gene discussed is NR4A1; the disease is brain ischemia.