While both XN and TXN improved 11 phenotypic parameters, including fasting LDL, fasting cholesterol, and brown adipose tissue (BAT) weight, only TXN demonstrated a significant improvement of parameters associated with diabetes, including HOMA-IR, fasting insulin, and MAFLD markers like liver TAGs, mesenteric fat pad weight, and total fat percent. This evidence concerns the gene INS and diabetes mellitus.