HK2 and cancer: The anti-cancer properties of traditional Chinese compounds have been investigated in detail and include Oleanolic acid, Carpesium abrotanoides L, Tanshinone IIA, Dioscin, Polyphyllin VI, Euxanthone, Chrysin, etc. many of these compounds affect glucose enzymes and/or transporters, including GLUT1, HK2, LDHA, HIF-1α, PFK1, and PKM2 [260].