Additionally, knocking down hexokinase-1 (HK-1) in OCI-AML3 cells and U937, and treating the aforementioned AML cell lines and actual AML blasts with the glycolysis blocker 2-deoxy-D-glucose (2-DG), enhanced the chemotherapeutic drug cytosine arabinoside (Ara-C) sensitivity [241]. Here, HK1 is linked to acute myeloid leukemia.