Furthermore, several monoclonal antibodies (HuMV833), small molecule VEGFR kinase inhibitors (SU5416, SU6668, SU11248, and ZD6474 in addition to soluble VEGF receptors (VEGF-Trap) and ribozymes (AngiozymeTM) have been investigated by various cancer therapy companies for their ability to inhibit VEGF or VEGFR in cancer therapy for AML [322]. The gene discussed is KDR; the disease is acute myeloid leukemia.