The results of our study show that R-EXO-miR-24-3p leads to T-cell apoptosis by targeting DENN/MADD and consequently inhibiting the activity of NF-κB, JAK/STAT and ERK in the MAPK signaling pathways and promoting Tregs, contributing to cancer tolerance in the tumor microenvironment (TME). The gene discussed is NFKB1; the disease is cancer.