Moreover, we found that DENN/MADD was downregulated in the T cells of leukemia patients compared to HDs (p < 0.006) (Fig. 4C) and was inversely correlated with increased exosomal miR-24-3p and miR-24-3p levels in the CD3 T cells of leukemia patients (Fig. 4D and E). Here, MADD is linked to leukemia.