Consistent with expectations, we further explored the effects of cellular components, cellular communication, transcription factors and ligand receptors in the TME of STAD patients on ICB treatment response and found that CD8 T cells, neutrophil-B cells, NK cells-CD8 T cells, and STAT4-SDC4 were strong positive biomarkers of ICB treatment response in STAD patients. The gene discussed is SDC4; the disease is gastric adenocarcinoma.