Our hypothesis is that cytoplasmic Mir100hg augments the metastatic activity of lung cancer cells by targeting miR-15a-5p and miR-31-5p and acting through the CeRNA regulatory mechanism that leads to the relief of the tumor suppressive activity of miR-15a-5p and miR-31-5p. The gene discussed is MIR100HG; the disease is lung carcinoma.