CD274 and neoplasm: The micelleplex utilized a pH-responsive diblock copolymer poly(ethylene glycol)-block poly(diisopropanol amino ethyl methacrylate-cohydroxyethyl methacrylate) (PEG-b-P(DPA-co-HEA) (PDPA), that grafted with a photosensitizer of Pheophorbide A (PPa), and 1,2-epoxytetradecane alkylated oligoethyleneimine (OEI-C14), which is necessary for siRNA complexation and delivery, and the siPD-L1 to silence the PD-L1 expression on the surface of tumor cell.