AKT1 and perinatal asphyxia: To show the interaction and crosstalk between PI3K/AKT and Wnt/β-catenin pathways, Saraceno et al. [42] demonstrated that perinatal asphyxia (PA) affects the IGF receptor (IGFR)/PI3K/AKT/GSK3β/β-catenin signalling pathways in neuroprotection and neuronal plasticity.