The results showed that the expression of CASC7 in serum of patients with HCC was significantly higher than that of patients with CHB (median: 8.8 versus 2.2 copies/μl, p < 0.001) and healthy controls (median: 8.8 versus 3.8 copies/μl, p < 0.001). This evidence concerns the gene AGO2 and hepatocellular carcinoma.