Recent studies have shown that some lncRNAs play an important role in HBV-related diseases, especially in the process of carcinogenesis, such as lncRNA Dreh, which inhibits the metastasis of hepatocellular carcinoma and is down-regulated by HBx, and lncRNA ZNRD1-AS1, which affects both HBV infection and the occurrence of hepatocellular carcinoma [39, 40]. This evidence concerns the gene POLR1H and hepatocellular carcinoma.