To further explore whether it is involved in the development of HCC, we investigated the association of CASC7 with clinicopathological characteristics, and found that high expression of serum CASC7 was associated to varying degrees with multiple well known risk factors for HCC, including tumor number, IM, tumor size and TNM stage, suggesting its role in predicting progression and dynamics of tumor. Here, AGO2 is linked to hepatocellular carcinoma.