The results showed that, CASC7 level in HCC serum samples was much higher when compared to the patients with CHB (median: 8.8 versus 2.2 copies/μl, p < 0.001) and to the healthy controls (median: 8.8 versus 3.8 copies/μl, p < 0.001), but there was no significant difference between CHB group and normal group (p = 0.094) (Fig. 1a). The gene discussed is AGO2; the disease is hepatocellular carcinoma.