NFAT protein family is the main substrate of CaN and includes NFAT1 (NFATc2), NFAT2 (NFATc1), NFAT3 (NFATc4), NFAT4 (NFATc3) and NFAT5, among which NFATc3 protein is highly related to the development of cardiovascular disease [7]. Here, NUP214 is linked to cardiovascular disorder.