mRNA in situ hybridization for Lrig1 (upper HF), Lgr6 (IFE and upper HF), and Lgr5 (bulge) following injury revealed that Myc deletion resulted in fewer Lrig1+ cells (Fig. 4i,j), whereas Lgr5 and Lgr6 expression was unaffected (Extended Data Fig. 4h,i). This evidence concerns the gene LRIG1 and hydrops fetalis.