Furthermore, resident (Tim4+) Kupffer cells had significantly lower Lepr expression in an experimental NASH model than in control mice, and expression of Lepr was minimal in peripheral blood monocytes and recruited monocyte-derived (Tim4–) Kupffer cells in C57BL/6J mice with NASH (Fig. 3f)32. Here, TIMD4 is linked to metabolic dysfunction-associated steatohepatitis.