The SHAP analysis showed that established prognostic factors such as tumor malignancy (p-Stage, pathological N status, histological type, pleural invasion, lymphatic invasion, standard uptake value (SUV)-max, carcinoembryonic antigen [CEA], and cytokeratin-19 fragments [CYFRA]), pulmonary function, and smoking history were still the top variables affecting the prognosis of NSCLC. The gene discussed is CEACAM5; the disease is neoplasm.