When looking at each variable, established prognostic factors such as tumor malignancy (p-Stage, pathological N status, histological type, pleural invasion, lymphatic invasion, SUV-max, CEA, and CYFRA), pulmonary function, and smoking history were still the top factors affecting the prognosis of NSCLC; therefore, the validity of the evaluation by SHAP values is high. Here, CEACAM5 is linked to non-small cell lung carcinoma.